Abnova/CCND1/CEN11q FISH Probe/1kit/FG0113
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美元价：
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联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
- Quality Control Testing:
- Representative images of human cell stain with the dual color FISH probe. The left image is two copies of CCND1 gene and two copies of chromosome 11 in HL60S cell line; and the right image is two copies of chromosome 11 and higher copy number of CCND1 gene (amplification) in SKMEL2 cell line.
- Storage Instruction:
- Store at -20°C in the dark.
- Note:
- Hybridization position of the probes on the chromosome.
- Probe 1:Size:Fluorophore:Location:
- CCND1Approximately 162kbOrange11q13
- Probe 2:Size:Fluorophore:Location:
- CEN11qApproximately 0.68kbGreen11p11.11-q11
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Datasheet:
Download
- Publication Reference
- 1.
- Detection of CCND1 Locus Amplification by Fluorescence In Situ Hybridization.Balázs M, Koroknai V, Szász I, Ecsedi S.Methods Mol Biol. 2018;1726:85-100.
- 2.
- Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.Korshunov A, Ryzhova M, Hovestadt V, Bender S, Sturm D, Capper D, Meyer J, Schrimpf D, Kool M, Northcott PA, Zheludkova O, Milde T, Witt O, Kulozik AE, Reifenberger G, Jabado N, Perry A, Lichter P, von Deimling A, Pfister SM, Jones DT.Acta Neuropathol. 2015 May;129(5):669-78. Epub 2015 Mar 10.
- Applications
- Fluorescent In Situ Hybridization
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization
- Gene Information
- Entrez GeneID:
- 595
- Gene Name:
- CCND1
- Gene Alias:
- BCL1,D11S287E,PRAD1,U21B31
- Gene Description:
- cyclin D1
- Omim ID:
- 151400, 168461, 193300, 254500
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
- Other Designations:
- B-cell CLL/lymphoma 1,G1/S-specific cyclin D1
- Gene Pathway
- Acute myeloid leukemia
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Focal adhesion
- Glioma
- Jak-STAT signaling pathway
- Melanoma
- Non-small cell lung cancer
- p53 signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Adenoma
- Ataxia telangiectasia
- Barrett Esophagus
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Breast Neoplasms, Male
- Carcinoma
- Carcinoma in Situ
- Carcinoma, Basal Cell
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
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