Abnova/ATXN1单克隆抗体，克隆2F5/1kit/MAB10450
市场价：
¥0.00
美元价：
0.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant ATXN1.
- Immunogen:
- Recombinant protein corresponding to human ATXN1.
- Host:
- Mouse
- Theoretical MW (kDa):
- 87
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Recommend Usage:
- Western Blot (1:500-1:2000)Immunohistochemistry (1:200-1:1000)Immunofluorescence (1:200-1:1000)Flow Cytometry (1:200-1:400)ELISA (1:10000)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In ascitic (0.03% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis using ATXN1 monoclonal antibody, clone 2F5 (Cat # MAB10450) against HEK293 (1) and ATXN1-hIgGFc transfected HEK293 (2) cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue (A) and lung cancer tissue (B) using ATXN1 monoclonal antibody, clone 2F5 (Cat # MAB10450) with DAB staining.
- Immunofluorescence
- Immunofluorescence analysis of NTERA-2 cells using ATXN1 monoclonal antibody, clone 2F5 (Cat # MAB10450) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
- Enzyme-linked Immunoabsorbent Assay
- Flow Cytometry
- Flow cytometric analysis of Jurkat cells using ATXN1 monoclonal antibody, clone 2F5 (Cat # MAB10450) (green) and negative control (purple).
- Application Image
- Western Blot (Transfected lysate)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunofluorescence
- enlarge
- Enzyme-linked Immunoabsorbent Assay
- Flow Cytometry
- enlarge
- Gene Information
- Entrez GeneID:
- 6310
- Gene Name:
- ATXN1
- Gene Alias:
- ATX1,D6S504E,SCA1
- Gene Description:
- ataxin 1
- Omim ID:
- 164400, 601556
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure" cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016065,OTTHUMP00000039306,olivopontocerebellar ataxia 1, autosomal dominant,spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
- Related Disease
- Alzheimer Disease
- Bipolar Disorder
- Cerebellar Ataxia
- Chronic Disease
- Cognition
- Dementia, Vascular
- Diseases in Twins
- Epilepsy
- Fragile X Syndrome
- Fragile X syndrome
- Friedreich Ataxia
- Friedreich"s ataxia
- Genetic Predisposition to Disease
- Genomic Instability
- Huntington Disease
- Huntington disease
- Machado-Joseph Disease
- Muscular Atrophy, Spinal
- Myoclonic Epilepsies, Progressive
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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