Abnova/ROS1分体式CISH探头/1kit/CS0014
市场价：
¥0.00
美元价：
0.00
产品分类：
生化标准品
公司分类：
Biochemical_standard
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- ROS1 Split CISH Probe is designed for the qualitative detection of human ROS1 gene at 6q22.1 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:1. Digoxigenin-labeled polynucleotides targeting sequences mapping in 6q22.1* (chr6:117,448,964-117,627,255) proximal to the ROS1 breakpoint region2. Dinitrophenyl-labeled polynucleotides targeting sequences mapping in 6q22.1* (chr6:117,659,135-117,871,701) distal to the ROS1 breakpoint region 3. Formamide based hybridization buffer*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green colored distinct dotshaped (proximal to the ROS1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the ROS1 breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the ROS1 gene region, two red/green fusion signals appear.Aberrant situation: One ROS1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Isolated green signals are the result of deletions distal to the ROS1 breakpoint region or are due to unbalanced translocations affecting this chromosomal region. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements. Unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (FFPE Tissue)
- Lung cancer tissue section with rearrangement of the ROS1 gene as indicated by isolated green signals.
- Chromogenic In Situ Hybridization (Cells)
- Normal interphase cells as indicated by two red/green fusion signals per nucleus.
- Application Image
- Chromogenic In Situ Hybridization (FFPE Tissue)
- enlarge
- Chromogenic In Situ Hybridization (Cells)
- enlarge
- Gene Information
- Entrez GeneID:
- 6098
- Gene Name:
- ROS1
- Gene Alias:
- MCF3,ROS,c-ros-1
- Gene Description:
- c-ros oncogene 1 , receptor tyrosine kinase
- Omim ID:
- 165020
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq
- Other Designations:
- OTTHUMP00000017814,OTTHUMP00000040389,proto-oncogene c-ros-1 protein,proto-oncogene tyrosine-protein kinase ROS,transmembrane tyrosine-specific protein kinase,v-ros UR2 sarcoma virus oncogene homolog 1,v-ros avian UR2 sarcoma virus oncogene homolog 1
- Related Disease
- Atherosclerosis
- Brain Ischemia
- Cardiovascular Diseases
- Cerebral Hemorrhage
- Coronary Artery Disease
- Coronary Disease
- Coronary Restenosis
- Genetic Predisposition to Disease
- Hypertension
- Kidney Failure, Chronic
- Lung Neoplasms
- Metabolic Syndrome X
- Myocardial Infarction
- Pulmonary Disease, Chronic Obstructive
- Renal Insufficiency, Chronic
- Stroke
- Tobacco Use Disorder
- Urinary Bladder Neoplasms
- Werner syndrome
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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