Abnova/MYC分体式CISH探头/1kit/CG0011
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- MYC Split CISH Probe is designed for the qualitative detection of human MYC gene at 8q24.21 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:1. Digoxigenin-labeled polynucleotides targeting sequences mapping in 8q24.21* (chr8:130,373,051-130,847,951) distal to the MYC breakpoint region2. Dinitrophenyl-labeled polynucleotides targeting sequences mapping in 8q24.21* (chr8:127,888,765-128,363,281) proximal to the MYC breakpoint region 3. Formamide based hybridization buffer*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (distal to the MYC breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (proximal to the MYC breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the MYC gene region, two red/green fusion signals appear.Aberrant situation: One MYC gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements. Unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (FFPE Tissue)
- Non-Hodgkin lymphoma tissue section with translocation affecting the 8q24.21 locus as indicated by one red/green fusion (non-rearranged) signal, one red signal, and one separate green signal.
- Chromogenic In Situ Hybridization (Cells)
- Normal interphase cells as indicated by two red/green fusion signals per nucleus.
- Application Image
- Chromogenic In Situ Hybridization (FFPE Tissue)
- enlarge
- Chromogenic In Situ Hybridization (Cells)
- enlarge
- Gene Information
- Entrez GeneID:
- 4609
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Omim ID:
- 113970, 190080
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
- Gene Pathway
- Acute myeloid leukemia
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Pathways in cancer
- Small cell lung cancer
- TGF-beta signaling pathway
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Lung Neoplasms
- Lymphoma, B-Cell
- Lymphoma, B-Cell, Marginal Zone
品牌介绍
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