Abnova/MALT1分体式CISH探头/1kit/CS0012
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美元价：
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产品分类：
RNA修饰酶
公司分类：
RNA_enzymes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- MALT1 Split CISH Probe is designed for the qualitative detection of human MALT1 gene at 18q21.32 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:1. Digoxigenin-labeled polynucleotides targeting sequences mapping in 18q21.31-q21.32* (chr18:56,021,766-56,202,885) proximal to the MALT1 breakpoint region2. Dinitrophenyl-labeled polynucleotides targeting sequences mapping in 18q21.32* (chr18:56,557,814-56,724,408) distal to the MALT1 breakpoint region 3. Formamide based hybridization buffer*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear dark green distinct dot-shaped (proximal to the MALT1 breakpoint region), and dinitrophenyl-labeled polynucleotides appear bright red distinct dot-shaped (distal to the MALT1 breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the MALT1 gene region, two red/green fusion signals appear. Aberrant situation: One MALT1 gene region affected by a translocation is indicated by one separate green signal and one separate red signal. Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements. Unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (Cells)
- Normal interphase cells as indicated by two red/green fusion signals per nucleus.
- Application Image
- Chromogenic In Situ Hybridization (Cells)
- enlarge
- Gene Information
- Entrez GeneID:
- 10892
- Gene Name:
- MALT1
- Gene Alias:
- DKFZp434L132,MLT,MLT1
- Gene Description:
- mucosa associated lymphoid tissue lymphoma translocation gene 1
- Omim ID:
- 604860
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- MALT associated translocation,MALT-lymphoma associated translocation,caspase-like protein,mucosa associated lymphoid tissue lymphoma translocation protein 1,paracaspase
- Gene Pathway
- B cell receptor signaling pathway
- T cell receptor signaling pathway
- Related Disease
- Gastritis
- Genetic Predisposition to Disease
- Helicobacter Infections
- Lymphoma, B-Cell, Marginal Zone
- Stomach Neoplasms
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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