Abnova/FUS分体式CISH探头/1kit/CS0010
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¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- FUS Split CISH Probe is designed for the qualitative detection of translocations involving the human FUS gene at 16p11.2 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:This Probe is composed of:1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 16p11.2* (chr16:30,663,949-30,840,569) distal to the FUS breakpoint region.2. Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 16p11.2* (chr16:31,213,259-31,927,155) proximal to the FUS breakpoint region. 3. Formamide based hybridization buffer.*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Interpretation of results:Using the CISH Implementation Kit 2 (Cat # KA5366), hybridization signals of Digoxigenin-labeled polynucleotides appear as dark green colored distinct dots (distal to the FUS breakpoint region), and Dinitrophenyl-labeled polynucleotides appear as bright red colored distinct dots (proximal to the FUS breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the FUS gene region, two red/green fusion signals appear.Aberrant situation: One FUS gene region affected by a translocation is indicated by one separate distinct dot-shaped green signal and one separate distinct dot-shaped red signal.Overlapping signals may appear as brown signals. Genomic aberrations due to small deletions, duplications or inversions might result in inconspicuous signal patterns. Other signal patterns than those described above may be observed in some abnormal samples. These unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (FFPE Tissue)
- Myxoid liposarcoma tissue section with translocation affecting the 16p11.2 locus as indicated by one non-rearranged red/green fusion signal, one red signal, and one separate green signal indicating the translocation.
- Application Image
- Chromogenic In Situ Hybridization (FFPE Tissue)
- enlarge
- Gene Information
- Entrez GeneID:
- 2521
- Gene Name:
- FUS
- Gene Alias:
- CHOP,FUS-CHOP,FUS1,TLS,TLS/CHOP,hnRNP-P2
- Gene Description:
- fusion (involved in t(12;16) in malignant liposarcoma)
- Omim ID:
- 137070
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq
- Other Designations:
- FUS-CHOP fusion protein,FUS-CHOP protein fusion,Fusion gene in myxoid liposarcoma,fus-like protein,fus/tls-chop oncogene,heterogeneous nuclear ribonucleoprotein P2,translocated in liposarcoma
- Related Disease
- Amyotrophic Lateral Sclerosis
- Azoospermia
- Cognition Disorders
- Diabetes Mellitus, Type 2
- Frontotemporal Dementia
- Frontotemporal Lobar Degeneration
- Genetic Predisposition to Disease
- Infertility, Male
- Neoplasms
- Neuropsychological Tests
- Obesity
- Obesity
- Oligospermia
- Overweight
- Parkinsonian Disorders
- Prostate cancer
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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