Abnova/ERG Split CISH Probe/1kit/CS0007
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美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- ERG Split CISH Probe is designed for the qualitative detection of translocations involving the human ERG gene at 21q22.2 in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:This Probe is composed of:1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 21q22.2* (chr21:40,078,039-40,269,979) distal to the ERG breakpoint region.2. Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 21q22.13- 21q22.2* (chr21:39,171,790-39,733,849) proximal to the ERG breakpoint region. 3. Formamide based hybridization buffer.*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Interpretation of results:Using the CISH Implementation Kit 2 (Cat # KA5366), hybridization signals of Digoxigenin-labeled polynucleotides appear as dark green colored distinct dots (distal to the ERG breakpoint region), and Dinitrophenyl-labeled polynucleotides appear as bright red colored distinct dots (proximal to the ERG breakpoint region).Normal situation: In interphases of normal cells or cells without a translocation involving the ERG gene region, two red/green fusion signals appear.Aberrant situation: In a cell with deletions affecting the ERG gene region resulting in the TMPRSS2-ERG fusion, the loss of one green signal will be observed. One ERG gene region affected by a translocation without involvement of TMPRSS2 (e.g, SLC45A3-ERG) is indicated by one separate green signal and one separate red signal.Overlapping signals may appear as brown signals. Genomic aberrations due to small deletions, duplications or inversions might result in inconspicuous signal patterns. Other signal patterns than those described above may be observed in some abnormal samples. These unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (FFPE Tissue)
- Prostate cancer tissue section with translocation affecting the 21q22.13-q22.2 locus as indicated by one non-rearranged red/green fusion signal, one red signal, and one separate green signal indicating the translocation.
- Application Image
- Chromogenic In Situ Hybridization (FFPE Tissue)
- enlarge
- Gene Information
- Entrez GeneID:
- 2078
- Gene Name:
- ERG
- Gene Alias:
- erg-3,p55
- Gene Description:
- v-ets erythroblastosis virus E26 oncogene homolog (avian)
- Omim ID:
- 165080
- Gene Ontology:
- Hyperlink
- Other Designations:
- OTTHUMP00000115970,TMPRSS2-ERG prostate cancer specific,transcriptional regulator ERG (transforming protein ERG),v-ets avian erythroblastosis virus E26 oncogene related,v-ets erythroblastosis virus E26 oncogene like
- Related Disease
- Adenocarcinoma
- Genetic Predisposition to Disease
- Osteoporosis, Postmenopausal
- Prostate cancer
- Prostatic Neoplasms
- Tobacco Use Disorder
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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