阿布诺瓦/穆塔菲什与贸易；c-Mycwt RNA探针/1kit/FP0015
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- mutaFISH™ c-Mycwt RNA Probes is designed to detect human c-Myc gene on single strand RNA in cells using padlock probe and in situ rolling-circle amplification technology.
- Supplied Product:
- Content:1. RT c-Myc Primer2. mutaFISH™ c-Mycwt RNA Probe3. Detection Probe-Texas Red X
- Storage Instruction:
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- We recommend mutaFISH™ RNA Accessory Kit (Catalog #: KA4915) which provides necessary reagents and enzymes for in situ reverse transcription, RNA digestion, mutaFISH™ hybridization, ligation and amplication prior to mutaFISH™.
- Protocol:
Protocol Download
- Technology:
- mutaFISH™ (mutation-specific Fluorescence In Situ Hybridization)
- Comparison:
- FISH Probes vs mutaFISH™ Probes
- Fluorophore:
- Texas Red X (Excitation Peak (nm): 595; Emission Peak613)
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Video:
- Datasheet:
- Download
- Applications
- mutation specific, Fluorescence In Situ Hybridization (Cells)
- mutaFISH™ staining was performed in situ in human H1975 cells. c-Myc was detected via red signal (Cy5).
- Application Image
- mutation specific, Fluorescence In Situ Hybridization (Cells)
- enlarge
- Gene Information
- Entrez GeneID:
- 4609
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Omim ID:
- 113970, 190080
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
- Gene Pathway
- Acute myeloid leukemia
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Pathways in cancer
- Small cell lung cancer
- TGF-beta signaling pathway
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Lung Neoplasms
- Lymphoma, B-Cell
- Lymphoma, B-Cell, Marginal Zone
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
联络我们
