Abnova/ACVR1B（人）匹配抗体对/1kit/H00000091-AP41
商品编号：
H00000091-AP41
品牌：
abnovadx
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACVR1B.
- Reactivity:
- Human
- Quality Control Testing:
- Standard curve using recombinant protein ( H00000091-Q01 ) as an analyte.
Sandwich ELISA detection sensitivity ranging from 10 ng/ml to 100 ng/ml.
- Supplied Product:
- Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACVR1B, IgG1 Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACVR1B, IgG1 Kappa (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
- Storage Instruction:
- Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
- Datasheet:
Download
- Applications
- ELISA Pair (Recombinant protein)
- Protocol Download
- Application Image
- ELISA Pair (Recombinant protein)
- Gene Information
- Entrez GeneID:
- 91
- Gene Name:
- ACVR1B
- Gene Alias:
- ACTRIB,ACVRLK4,ALK4,SKR2
- Gene Description:
- activin A receptor, type IB
- Omim ID:
- 601300
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
- Other Designations:
- activin A receptor, type II-like kinase 4,activin A type IB receptor,activin receptor-like kinase 4,serine(threonine) protein kinase receptor R2
- Gene Pathway
- Adherens junction
- Chronic myeloid leukemia
- Colorectal cancer
- Cytokine-cytokine receptor interaction
- Endocytosis
- MAPK signaling pathway
- Pancreatic cancer
- Pathways in cancer
- TGF-beta signaling pathway
- Related Disease
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Obesity
- Ovarian Failure, Premature
- Polycystic Ovary Syndrome
- Puberty, Delayed
- Puberty, Precocious
- Schizophrenia
- Thrombophilia
- Tobacco Use Disorder
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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