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Abnova/ACTN4 purified rabbit polyclonal antibody/1kit/H00000081-E01P
Abnova/ACTN4 purified rabbit polyclonal antibody/1kit/H00000081-E01P
商品编号：
H00000081-E01P
品牌：
abnovadx
市场价：
¥0.00
美元价：
0.00
产品分类：
克隆基因
公司分类：
Cloned_Genes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against ACTN4 protein.
- Host:
- Rabbit
- Reactivity:
- Human
- Quality Control Testing:
- Antibody reactive against recombinant protein.
Western Blot detection against recombinant protein (58.41 KDa).
Western Blot detection against recombinant protein (131.3 KDa).
- Storage Buffer:
- In 1x PBS, pH 7.4
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Interspecies Antigen Sequence:
- Mouse (98); Rat (98)
- Datasheet:
Download
- Applications
- Western Blot
- ELISA
- Application Image
- Western Blot
- ELISA
- Gene Information
- Entrez GeneID:
- 81
- GeneBank Accession#:
- NM_004924.3
- Protein Accession#:
- NP_004915.2
- Gene Name:
- ACTN4
- Gene Alias:
- ACTININ-4,DKFZp686K23158,FSGS,FSGS1
- Gene Description:
- actinin, alpha 4
- Omim ID:
- 603278, 604638
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
- Other Designations:
- actinin alpha4 isoform
- Interactome
- Gene Pathway
- Adherens junction
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Focal adhesion
- Leukocyte transendothelial migration
- Regulation of actin cytoskeleton
- Systemic lupus erythematosus
- Tight junction
- Related Disease
- Alport syndrome
- Cardiovascular Diseases
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Edema
- Genetic Predisposition to Disease
- Glomerulosclerosis, Focal Segmental
- Kidney Diseases
- Proteinuria
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
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