Abnova/ABL1（磷酸Y204）多克隆抗体/1kit/PAB16961
市场价：
¥0.00
美元价：
0.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of ABL1.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding Y204 of human ABL1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody detects endogenous levels of ABL1 only when phosphorylated at tyrosine 204.
- Form:
- Liquid
- Recommend Usage:
- Western Blot (1:500-1:1000)Immunohistochemistry (1:50-1:100)ELISA (1:4000)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Publication Reference
- 1.
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ.Cell. 2007 Dec 14;131(6):1190-203.
- 2.
- Autoinhibition of c-Abl.Pluk H, Dorey K, Superti-Furga G.Cell. 2002 Jan 25;108(2):247-59.
- 3.
- JAK-STAT signaling activated by Abl oncogenes.Danial NN, Rothman P.Oncogene. 2000 May 15;19(21):2523-31.
- Applications
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1 (phospho Tyr204) polyclonal antibody (Cat # PAB16961).
- Enzyme-linked Immunoabsorbent Assay
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Enzyme-linked Immunoabsorbent Assay
- Gene Information
- Entrez GeneID:
- 25
- Protein Accession#:
- P00519
- Gene Name:
- ABL1
- Gene Alias:
- ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
- Gene Description:
- c-abl oncogene 1, receptor tyrosine kinase
- Omim ID:
- 189980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
- Other Designations:
- Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
- Gene Pathway
- Axon guidance
- Cell cycle
- Chronic myeloid leukemia
- ErbB signaling pathway
- Neurotrophin signaling pathway
- Pathogenic Escherichia coli infection - EHEC
- Pathways in cancer
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Chronic Disease
- Diabetes Complications
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- HIV Infections
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Chronic
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
- Ovarian cancer
品牌介绍
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