Abnova/ALK polyclonal antibody/1kit/PAB18081
市场价：
¥0.00
美元价：
0.00
产品分类：
克隆基因
公司分类：
Cloned_Genes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ALK.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1570-1619 of human ALK.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 176
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous levels of total ALK protein.
- Form:
- Liquid
- Recommend Usage:
- ELISA (1:1000)Immunofluorescence (1:100~1:500)Immunohistochemistry (1:50~1:100)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS ((without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
- Storage Instruction:
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Publication Reference
- 1.
- The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A, Dirks WG, Sexl V, Bergler H, Kadin ME, Sternberg DW, Kenner L, Hoefler G.Blood. 2007 Nov 1;110(9):3374-83. Epub 2007 Aug 9.
- 2.
- Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3.Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA.Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9964-9. Epub 2006 Jun 9.
- 3.
- Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype.Suzuki R, Kagami Y, Takeuchi K, Kami M, Okamoto M, Ichinohasama R, Mori N, Kojima M, Yoshino T, Yamabe H, Shiota M, Mori S, Ogura M, Hamajima N, Seto M, Suchi T, Morishima Y, Nakamura S.Blood. 2000 Nov 1;96(9):2993-3000.
- 4.
- Lymphomas expressing ALK fusion protein(s) other than NPM-ALK.Falini B, Pulford K, Pucciarini A, Carbone A, De Wolf-Peeters C, Cordell J, Fizzotti M, Santucci A, Pelicci PG, Pileri S, Campo E, Ott G, Delsol G, Mason DY.Blood. 1999 Nov 15;94(10):3509-15.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry analysis of paraffin-embedded human brain tissue using ALK polyclonal antibody (Cat # PAB18081).Peptide "+" means "with peptide blocking".
- Immunohistochemistry
- Immunofluorescence
- Immunofluorescence analysis of HeLa cells, using ALK polyclonal antibody (Cat # PAB18081).Peptide "+" means "with peptide blocking".
- Enzyme-linked Immunoabsorbent Assay
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry
- Immunofluorescence
- enlarge
- Enzyme-linked Immunoabsorbent Assay
- Gene Information
- Entrez GeneID:
- 238
- Protein Accession#:
- Q9UM73
- Gene Name:
- ALK
- Gene Alias:
- CD246,Ki-1,TFG/ALK
- Gene Description:
- anaplastic lymphoma receptor tyrosine kinase
- Omim ID:
- 105590
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
- Other Designations:
- ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
- Related Disease
- Adenocarcinoma
- Carcinoma, Non-Small-Cell Lung
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- Lung Neoplasms
- Multiple Sclerosis
- Schizophrenia
- Schizophrenia
- Tobacco Use Disorder
品牌介绍
Abnova是世界上最大的抗体制造商。亚诺法的所有产品，重组蛋白和抗体都是利用最新的技术及由SPF等级动物实验室制造生产出来。我们的目标是生产人类基因组内每个基因至少要有一个相对应的抗体，可以提供给来自于学术机构、行业的伙伴和合作者做研究。亚诺法有许多多样化的单克隆及多克隆抗体，我们更进一步开发一系列的整合系统与相关应用包含配对抗体、ELISA试剂盒与荧光原位杂交(FISH)探针。这些工具对生物标记开发与转译研究都是必须的。亚诺法亦有针对糖尿病、传染疾病与癌症的体外检验试剂专案以及用于治疗败血症的全人类抗体药技专案，为全人类的健康努力。
联络我们
